TRANSLATIONAL PHYSIOLOGY Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs

Robert E. Gerszten, Frank Accurso, Gordon R. Bernard, Richard M. Caprioli, Eric W. Klee, George G. Klee, Iftikhar Kullo, Theresa A. Laguna, Frederick P. Roth, Marc Sabatine, Pothur Srinivas, Thomas J. Wang, and Lorraine B. Ware for the NHLBI Clinical Proteomics Programs Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts; Department of Pediatrics, University of Colorado Denver and Health Sciences, Denver, Colorado; Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University, Nashville, Tennessee; Mass Spectrometry Research Center, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota; Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota; Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts; Cardiovascular Division, Brigham and Women’s Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts; and National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland